A Role for Syndecan-1 and Claudin-2 in Microbial Translocation During HIV-1 Infection
نویسندگان
چکیده
منابع مشابه
Microbial translocation: a marker of advanced HIV-1 infection and a predictor of treatment failure?
To the Editor—We agree that the issue of whether microbial translocation (MT) is a cause or consequence of human immunodeficiency virus type 1 (HIV-1) disease progression is an important question that can only be addressed through longitudinal analyses of natural history cohorts such as the study by Redd et al [1]. A timely and definitive answer to this question will depend on the availability ...
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BACKGROUND Systemic inflammation is a characteristic of both HIV-1 infection and aging ("inflammaging"). Intestinal epithelial barrier damage (IEBD) and microbial translocation (MT) contribute to HIV-associated inflammation, but their impact on inflammaging remains unclear. METHODS Plasma biomarkers for IEBD (iFABP), MT (LPS, sCD14), T-cell activation (sCD27), and inflammation (hsCRP, IL-6) w...
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متن کاملMicrobial translocation in the pathogenesis of HIV infection and AIDS.
In pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to portal and systemic circulation has been proposed as a major driver of the chronic immune activation that is associated with disease progression. Consistently, microbial translocation is not present in nonpathogenic ...
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ژورنال
عنوان ژورنال: JAIDS Journal of Acquired Immune Deficiency Syndromes
سال: 2010
ISSN: 1525-4135
DOI: 10.1097/qai.0b013e3181ecfeca